Twenty-eight of the 29 patients in the IRAD registry who had a dissection during pregnancy survived the hospitalization. Members include 57 active centers in 13 countries. Eagle started the International Registry of Acute Aortic Dissection, housed at Michigan Medicine, in 1996. "It's important to understand what these women experienced, including their risk factors, underlying medical conditions and ultimate outcomes, in order to learn how best to care for others and to prevent future aortic dissections in this population," he says. Given that aortic dissection is already rare, the ability to study a cohort of people who had the condition while pregnant provides an important opportunity, says senior author Kim Eagle, M.D., a director of the Michigan Medicine Frankel Cardiovascular Center and a professor of internal medicine. The participants who had a type B dissection were more likely to be given medication, although some received an open or minimally invasive heart surgery. Eighty-five percent of those women with a Type A dissection went into their pregnancies with a known diagnosis such as Marfan syndrome (the most common). Women in the cohort experienced dissections in all three trimesters of pregnancy in addition to within three months postpartum, although more cases occurred in the latter part of pregnancy and immediately following.Īll of the participants who had a Type A aortic dissection, the most dangerous, underwent surgery to repair the dissection. That means a woman already predisposed to have a dissection is more likely to have one during pregnancy, possibly due to hormones and changes to the body during pregnancy and postpartum. ![]() Notably, the researchers found 19% of aortic dissections in women younger than 35 years old were associated with pregnancy. A patient needs a timely diagnosis and then urgent, life-saving medical attention.Īortic diseases and conditions like Marfan syndrome or Loeys-Dietz syndrome are usually culprits in women who have a dissection while pregnant, the researchers say, although an association to high blood pressure, the most common risk factor in the general population, may exist, too. They cause the layers of the aorta to tear, and blood to pool or leak instead of flowing normally. Most already had an underlying heart condition, although it was often not yet diagnosed.Īortic dissections only affect 3 in 100,000 people per year. ![]() For a new investigation published in JAMA Cardiology, researchers studied the experiences of 29 participants in an international registry who were unexpectedly hospitalized for a dissection while pregnant.
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